miR-196a2

Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population

K. Yu, Ji, Y., Wang, H., Xuan, Q. K., Li, B. B., Xiao, J. J., Sun, W., and Kong, X. Q., Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population, vol. 15, no. 4, p. -, 2016.

INTRODUCTION

Congenital heart disease (CHD), defined as clinically structural heart defects present before and at birth, is the leading cause of serious infant morbidity and mortality worldwide. The incidence of CHD at birth was 10-12 per 1000 live births in 2013 (Hoffman, 2013). Similarly, in China the overall incidence based on epidemiological studies was 8 per 1000 live births in 2011, an approximate increase of 6.7 times compared with 1996 (Yu et al., 2014).

Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer

J. Y. Gu, Tu, L., Gu, J. Y., and Tu, L., Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer, vol. 15, p. -, 2016.

Here, we performed a case-control study to investigate the role of miR-146a, miR-149, and miR-196a2 polymorphisms in the development of gastric cancer using a hospital-based case-control design. A total of 186 gastric cancer patients and 186 control subjects were enrolled from Ren Ji Hospital between January 2012 and October 2014. MicroRNAs miR-146a, miR-149, and miR-196a2 were genotyped by polymerase chain reaction coupled with restriction fragment length polymorphism.

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