miR-34a

Clinical significance of microRNA-34a in esophageal squamous cell carcinoma

X. Lin, Xu, X. Y., Chen, Q. S., and Huang, C., Clinical significance of microRNA-34a in esophageal squamous cell carcinoma, vol. 14, pp. 17684-17691, 2015.

MicroRNA-34a (miR-34a) has been found to be downregulated in esophageal squamous cell carcinoma (ESCC) tissues compared with that in normal tissues (P

miR-34a targets the inhibin beta B gene, promoting granulosa cell apoptosis in the porcine ovary

F. Tu, Pan, Z. X., Yao, Y., Liu, H. L., Liu, S. R., Xie, Z., and Li, Q. F., miR-34a targets the inhibin beta B gene, promoting granulosa cell apoptosis in the porcine ovary, vol. 13, pp. 2504-2512, 2014.

During ovarian follicular growth and development, only a few follicles actually ovulate. Recently, it was found that follicular atresia is triggered by granulosa cell apoptosis, but the molecular mechanism of follicular atresia was not understood. Using flow cytometry, we found that miR-34a promotes granulosa cell apoptosis in pig ovarian follicles. In addition, inhibin beta B was found to be a miR-34a target gene, based on luciferase reporter assays, quantitative RT-PCR and Western blotting.

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