Mixed population

Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil

C. M. A. R. Barros, Araújo-Neto, A. P., Lopes, T. R., Barros, M. A. L., Motta, F. J. N., Canalle, R., Nunes, L. C. C., Rey, J. A., Burbano, R. R., Lima-Barros, M. A., Yoshioka, F. K. N., and Pinto, G. R., Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil, vol. 13, pp. 7889-7898, 2014.

Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have demonstrated a strong association of two polymorphic variations in the TCF7L2 gene, the noncoding single nucleotide polymorphisms (SNPs) rs7903146 (C/T) and rs12255372 (G/T), with T2D.

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