MKL1

MKL1-184C>T gene polymorphism is associated with coronary artery disease in the Chinese Han population

Y. Xu, Li, B., Bao, Y. - Z., Zhang, X. - Y., Zhu, Z. - Y., Zhao, X. - F., Shi, Y. - N., Li, D., Chen, S. - H., Guo, Y., and Cui, C. - H., MKL1-184C>T gene polymorphism is associated with coronary artery disease in the Chinese Han population, vol. 13, pp. 590-597, 2014.

We investigated genetic susceptibility to coronary artery disease (CAD) by studying the association of MKL1 gene polymorphisms with CAD in the Chinese Han population. We performed a case-control study with 476 unrelated CAD patients and 325 non-CAD controls. All SNPs were genotyped with a TaqMan SNP genotyping assay. The distribution of MKL1-184C>T gene polymorphism in each group was in Hardy-Weinberg equilibrium. The frequency of the MKL1 T allele in the CAD group was significantly higher than in the control group (38.6 vs 30.8%).

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