MLH1 gene

MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer

R. Muñiz-Mendoza, Ayala-Madrigal, M. L., Partida-Pérez, M., Peregrina-Sandoval, J., Leal-Ugarte, E., Macias-Gomez, N., Peralta-Leal, V., Meza-Espinoza, J. P., Moreno-Ortiz, J. M., Ramírez-Ramírez, R., Suárez-Villanueva, S., and Gutierrez-Angulo, M., MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer, vol. 11, pp. 2315-2320, 2012.

DNA repair proteins maintain DNA integrity; polymorphisms in genes coding for these proteins can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in Mexican patients. Genomic DNA samples were obtained from peripheral blood of 108 individuals with CRC (study group) at diagnosis and 120 blood donors (control group) from Western Mexico; both groups were mestizos. The polymorphisms were detected by PCR-RFLP.

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