MMP13

Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population

J. M. Moreno-Ortiz, Gutierrez-Angulo, M., Partida-Pérez, M., Peregrina-Sandoval, J., Ramírez-Ramírez, R., Muñiz-Mendoza, R., Suárez-Villanueva, S., Centeno-Flores, M., Maciel-Gutiérrez, V., Cabrales-Vazquez, J. E., and Ayala-Madrigal, M. L., Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population, vol. 13, pp. 3537-3544, 2014.

Colorectal cancer (CRC) is characterized by enhanced expression and activity of several metalloproteinases (MMPs), including MMP13 and MMP7, which play an important role in tumor invasion and metastasis. The objective of this study was to analyze the association of functional MMP7-181A/G and MMP13-77A/G promoter polymorphisms with susceptibility to CRC in a Mexican population. Genomic DNA samples were obtained from peripheral blood of 102 CRC patients and 125 blood donors who were included as the control group.

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