Morphine

Protective effects of morphine preconditioning in delayed phase on myocardial ischemia-reperfusion injury in rabbits

X. - H. Lu, Ran, K., Xiao, Y. - Y., Yang, D. - L., Chang, Y. - T., Duan, K. - M., and Ou, Y. - W., Protective effects of morphine preconditioning in delayed phase on myocardial ischemia-reperfusion injury in rabbits, vol. 14, pp. 8947-8954, 2015.

The aim of this study was to investigate the protective mechanisms of delayed-phase morphine preconditioning on myocardial ischemia-reperfusion injury. Thirty healthy male New Zealand white rabbits were randomly divided into three groups: a sham operation group (C), ischemia-reperfusion group (I/R), and delayed-phase morphine preconditioning group (M) (N = 10/group). Rabbits in the C group received thoracotomy for 160 min. Rabbits in the I/R group received left artery blockage for 40 min and reperfusion for 120 min.

Dopamine receptor D1 but not D3 essential for morphine-induced conditioned responses

Y. P. Wang, Wei, S. G., Zhu, Y. S., Zhao, B., Xun, X., and Lai, J. H., Dopamine receptor D1 but not D3 essential for morphine-induced conditioned responses, vol. 14, pp. 180-189, 2015.

Recent studies indicate the involvement of dopamine receptors D1 and D3 in the regulation of locomotor stimulant and conditioned responses to morphine in mice. Moreover, expression of brain-derived neurotrophic factor (BDNF) may be modulated by D1 and D3 receptor activities in the nucleus accumbens (NAc) and prefrontal cortex (PFC). However, the underlying interactions between D1 and D3 receptors and BDNF in the expression of behavioral responses controlled by drug-associated cues have not yet been fully elucidated.

Effect of morphine preconditioning in the delayed phase on the expression of p38 mitogen-activated protein kinase in a rabbit model of myocardial ischemia-reperfusion injury

K. Ran, Gong, Z. X., Yang, D. L., Chang, Y. T., Duan, K. M., and Ou, Y. W., Effect of morphine preconditioning in the delayed phase on the expression of p38 mitogen-activated protein kinase in a rabbit model of myocardial ischemia-reperfusion injury, vol. 14, pp. 6642-6648, 2015.

This study aimed to investigate the protective effects of delayed morphine preconditioning on myocardial ischemia-reperfusion injury. We randomly divided 30 rabbits into three groups with 10 rab­bits in each group as follows: sham operation group (C group), isch­emia-reperfusion group (I/R group), and morphine pretreatment group (M group). Rabbits in C Group received left coronary without blocking for 160 min. The left descending artery of rabbits in the I/R group was blocked for 40 min and reperfused for 120 min.

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