Myeloma

Autophagy in drug resistance of the multiple myeloma cell line RPMI8226 to doxorubicin

Y. - Z. Pan, Wang, X., Bai, H., Wang, C. - B., Zhang, Q., and Xi, R., Autophagy in drug resistance of the multiple myeloma cell line RPMI8226 to doxorubicin, vol. 14, pp. 5621-5629, 2015.

We investigated the effect of autophagy on drug resistance of multiple myeloma (MM) to doxorubicin (DOX). A DOX-resistant MM cell line (RPMI8226/DOX) was developed by progressively increasing the DOX concentration gradient. The drug resistance index was determined using the MTT method. Transmission electron microscopy, anti-light chain 3-fluorescein isothiocyanate immunofluorescence, and Western blotting were used to detect autophagy of MM cells.

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