Myocardial infarction

Effect of IL-1β, IL-8, and IL-10 polymorphisms on the development of myocardial infarction

S. Wang, Dai, Y. X., Chen, L. L., Jiang, T., Zheng, M. Q., Li, C. G., Chen, Y. P., Lin, W. H., Zhang, J. F., and Jiang, J., “Effect of IL-1β, IL-8, and IL-10 polymorphisms on the development of myocardial infarction”, vol. 14, pp. 12016-12021, 2015.

Myocardial infarction (MI) is currently a leading cause of death worldwide, and is caused by various environmental and genetic factors. We therefore conducted a case-control study to investigate the association between polymorphisms in interleukins IL-1β, IL-8, and IL-10 and MI risk. This study recruited 260 MI patients and 285 control subjects. Genotyping of IL-1β +3954C/T, IL-8 -251T/A, IL-10 -1082A/G, and IL-10 -819C/T were assessed using the polymerase chain reaction-restriction fragment length polymorphism method.

ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be directly correlated with cardiovascular disease risk

N. Jiang, Yang, G., and Peng, C. L., “ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be directly correlated with cardiovascular disease risk”, vol. 14, pp. 13932-13944, 2015.

The aim of this meta-analysis was to evaluate the correlations between the estrogen receptor 1 (ESR1) gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) and the risk of cardiovascular disease (CVD). Case-control studies were screened and selected from a larger group of studies that were retrieved through a comprehensive search of scientific literature databases, which was complemented by manual searches. Data from studies selected were analyzed using the Comprehensive Meta-analysis 2.0 software.

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