Myocardial ischemia-reperfusion

Effect of total peony glucoside pretreatment on NF-κB and ICAM-1 expression in myocardial tissue of rat with myocardial ischemia-reperfusion injury

L. Lu, Wei, P., Cao, Y., Zhang, Q., Liu, M., Liu, X. D., Wang, Z. L., Zhang, P. Y., Lu, L., Wei, P., Cao, Y., Zhang, Q., Liu, M., Liu, X. D., Wang, Z. L., and Zhang, P. Y., Effect of total peony glucoside pretreatment on NF-κB and ICAM-1 expression in myocardial tissue of rat with myocardial ischemia-reperfusion injury, vol. 15, no. 4, p. -, 2016.

INTRODUCTION

Fast, effective recovery of the coronary blood flow, after myocardial ischemia, is an effective method to treat this ischemia. However, myocardial ischemia-reperfusion (I/R) can aggravate ischemia-induced cardiac dysfunction and myocardial cell damage, leading to intracellular calcium overload, apoptosis, and inflammation. Therefore, clarifying its mechanism is important for the prevention of myocardial I/R injury.

Effect and mechanism of miR-126 in myocardial ischemia reperfusion

B. Li, Tao, Y., and Huang, Q., Effect and mechanism of miR-126 in myocardial ischemia reperfusion, vol. 14, pp. 18990-18998, 2015.

Multiple studies have shown microRNAs to play an important role in disease occurrence and development. The role of miRNAs in ischemia-reperfusion injury, however, requires further investigation and the aim of this study was therefore to assess miR-126 expression in myocardial ischemia reperfusion and the effects of miR-126 on myocardial ischemia-reperfusion injury. An in vitro model of ischemia-reperfusion injury was established using rat myocardial H9c2 cells and miR-126 expression in these cells was assessed by real-time PCR.

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