Nanofiber

Nanofibers promote HepG2 aggregate formation and cellular function

W. T. Su, Liu, Y. J., Huang, T. Y., Su, W. T., Liu, Y. J., and Huang, T. Y., Nanofibers promote HepG2 aggregate formation and cellular function, vol. 15, p. -, 2016.

Formation of hepatocyte spheroids is a necessary strategy for increasing liver-specific function in vitro. In this study, HepG2 cells showed good viability when grown on a polylactic acid-chitosan (PLA-CS) nanofiber and aggregated to form multicellular spheroids on the PLA-CS nanofibers with a diameter of approximately 100-200 mm in 5 days of culture, whereas no such aggregation was observed in cells cultured on 24-well plates.

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