NAT2 slow acetylation

Meta-analysis of the relationship between slow acetylation of N-acetyl transferase 2 and the risk of bladder cancer

Y. An, Li, H., Wang, K. J., Liu, X. H., Qiu, M. X., Liao, Y., Huang, J. L., and Wang, X. S., Meta-analysis of the relationship between slow acetylation of N-acetyl transferase 2 and the risk of bladder cancer, vol. 14, pp. 16896-16904, 2015.

The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). Many studies have indicated that slow acetylation of NAT2 increases the risk of bladder cancer. The major risk factor is tobacco smoke; however, some studies have failed to prove this. This study attempted to explore the correlation between NAT2 slow acetylation and bladder cancer risk through a meta-analysis of published case-control studies.

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