Nephrotic syndrome

Clinicopathological analysis of idiopathic membranous nephropathy in young adults

Y. Wang, Wang, G. P., Li, B. M., and Chen, Q. K., Clinicopathological analysis of idiopathic membranous nephropathy in young adults, vol. 14, pp. 4541-4548, 2015.

The aim of this study was to understand the clinicopath­ological features and prognosis of idiopathic membranous nephropa­thy (IMN) in youth. A retrospective analysis of the clinicopathological features and prognoses of pathologically confirmed IMN in 21 patients aged 15-30 years was performed. IMN was mainly characterized as nephrotic syndrome (NS), with stage I as the main pathological stage, and associated with hyperplasia of the glomerular mesangial cells and ground substance.

Effects of lovastatin on hepatic expression of the low-density lipoprotein receptor in nephrotic rats

L. X. Wei, Chen, L., Wang, W. M., Zhang, X. H., Wu, J. B., Liang, S. F., and Shu, G. Y., Effects of lovastatin on hepatic expression of the low-density lipoprotein receptor in nephrotic rats, vol. 13, pp. 938-944, 2014.

To investigate the effect of the HMG-CoA reductase inhibitor lovastatin on the expression of the receptor for hepatic low-density lipoprotein (LDL) in a rat model with kidney disease, and to identify the mechanisms in statin treatment of nephrotic syndrome with hyperlipidemia, a rat model with nephrotic syndrome was established. Thirty male Sprague-Dawley rats were treated with lovastatin for 2 weeks using gavage.

Comparative analysis of bilirubin in correlation to albumin between nephrotic syndrome patients and postoperative gastroparesis syndrome patients

M. H. Song, Zhu, G. J., Ma, L., Chen, G. L., Yang, D., Gong, J. H., Xie, Y. X., Yan, Y., and Wang, M. C., Comparative analysis of bilirubin in correlation to albumin between nephrotic syndrome patients and postoperative gastroparesis syndrome patients, vol. 13, pp. 9403-9411, 2014.

This study aimed to disclose the potential causality of low bilirubin in patients with nephrotic syndrome (NS). Correlation analysis was carried out on total bilirubin (TBIL) to serum albumin (ALB), urine protein (Upr), and urinary microalbumin/creatinine (Umalb/cr) for three groups in a case-control study.

Serum lipid abnormalities are not associated with apoB 3' VNTR polymorphism in nephrotic children

P. Hu, Hu, B., Qin, Y. H., Lu, L., Li, Z. Q., Tao, L. Q., Pei, Q., and Chen, J., Serum lipid abnormalities are not associated with apoB 3' VNTR polymorphism in nephrotic children, vol. 12, pp. 765-774, 2013.

Apolipoprotein B (apoB) gene 3' variable number of tandem repeat (VNTR) is highly variable, and therefore can be an informative marker for associative analysis of lipid metabolism. This is the first report focusing on a possible association of apoB VNTR polymorphism with nephrotic hyperlipidemia. Genomic DNA was extracted from 500 children with primary nephrotic syndrome (PNS) and 500 healthy controls. The apoB genotype was determined by PCR analysis.

Mutations in NPHS2 (podocin) in Mexican children with nephrotic syndrome who respond to standard steroid treatment

J. S. Carrasco-Miranda, Garcia-Alvarez, R., Sotelo-Mundo, R. R., Valenzuela, O., Islas-Osuna, M. A., and Sotelo-Cruz, N., Mutations in NPHS2 (podocin) in Mexican children with nephrotic syndrome who respond to standard steroid treatment, vol. 12. pp. 2102-2107, 2013.

Human nephrotic syndrome has been related to mutations in glomerular proteins. Mutations in the NPHS2 gene that encodes podocin have been described as responsible for steroid-resistant nephrotic syndrome. It has been advised to test for NPHS2 mutations in parallel or before giving steroid treatment in nephrotic syndrome patients in order to avoid unnecessary therapy. We identified NPHS2 mutations in Mexican children with nephrotic syndrome.

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