Nerve growth factor

Study of the relationship between the expression of nerve growth factor and aneurysm formation and prognosis

C. D. Wang, Wang, D. K., Cao, P. C., Wang, Z. W., Wang, Z., and Wang, Y. T., Study of the relationship between the expression of nerve growth factor and aneurysm formation and prognosis, vol. 14, pp. 4269-4275, 2015.

We sought to investigate the effect of nerve growth factor (NGF) expression on the formation and prognosis of cerebral aneurysms. Forty-eight cases were selected following a diagnosis of cerebral aneurysm using computed tomography angiography and surgical confirmation. Thirty-four cases of healthy deaths were also chosen. The tissue was tested for NGF expression changes by reverse-transcription PCR, Western blot and histopathology, and NGF expression was compared between the cerebral aneurysm and healthy groups.

Construction and identification of pIRES2-NGF-VEGF165 bicistronic eukaryotic expression vector

B. N. Li, Li, W. D., Feng, H. G., Lin, J. T., and Yuan, Z. Q., Construction and identification of pIRES2-NGF-VEGF165 bicistronic eukaryotic expression vector, vol. 13, pp. 5674-5685, 2014.

We used a simple and efficient method to construct the bicistronic eukaryotic expression vector pIRES2-NGF-VEGF165. The nerve growth factor (NGF) gene was obtained from the genomic DNA of human peripheral blood mononuclear cells by polymerase chain reaction. The NGF cDNA fragment was inserted into the multiple cloning sites of the pIRES2-EGFP vector to generate the bicistronic eukaryotic expression plasmid pIRES2-NGF-EGFP.

Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway

J. Zhang and Ma, W. Y., Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway, vol. 13, pp. 9324-9335, 2014.

Decades of research have provided the data to confirm the hypothesis that there is bidirectional communication between the central nervous system and the immune system in psoriasis pathogenesis, but the contribution of the cutaneous neural system remains underexplored. In this study, we evaluated the molecular mechanisms by which nerve growth factor (NGF) regulates hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) production. The mRNA and protein levels of VEGF secretion from HaCaT cells by NGF were increased in a concentration-dependent manner.

Neural-endocrine mechanisms of respiratory syncytial virus-associated asthma in a rat model

Q. G. Li, Wu, X. R., Li, X. Z., Yu, J., Xia, Y., Wang, A. P., and Wang, J., Neural-endocrine mechanisms of respiratory syncytial virus-associated asthma in a rat model, vol. 11, pp. 2780-2789, 2012.

We examined the underlying neural-endocrine mechanisms of asthma associated with respiratory syncytial virus infection. Thirty Sprague-Dawley rats were randomly divided into control group, respiratory syncytial virus (RSV) group, and anti-nerve growth factor (NGF) IgG group. An RSV infection model was established by nasal drip once a week. In the anti-NGF antibody intervention group, each rat was given an intraperitoneal injection of anti-NGF IgG 3 h before RSV infection.

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