Neural tube defects

Lack of association between the methylenetetrahydropholate reductase gene A1298C polymorphism and neural tube defects in a Turkish study group

S. H. Yildiz, M. Erdogan, O., Solak, M., Eser, O., Terzi, E. S. Arıkan, Eser, B., Kocabaş, V., Aslan, A., Yildiz, S. H., M. Erdogan, O., Solak, M., Eser, O., Terzi, E. S. Arıkan, Eser, B., Kocabaş, V., and Aslan, A., Lack of association between the methylenetetrahydropholate reductase gene A1298C polymorphism and neural tube defects in a Turkish study group, vol. 15, p. -, 2016.

The etiology underlying neural tube defects (NTDs) is not fully understood and is believed to involve a complex milieu of genetic and environmental factors. The A1298C polymorphism in the methylenetetrahydropholate reductase gene (MTHFR) has been associated with mild risk for NTDs. In this study, the genotype distribution of the MTHFR gene A1298C polymorphism and the levels of serum homocysteine, vitamin B12, and folate were evaluated in 33 children with NTDs, their mothers, and 46 healthy controls.

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