Differential expression of E-cadherin gene in human neuroepithelial tumors
“Differential expression of E-cadherin gene in human neuroepithelial tumors”, vol. 7, pp. 295-304, 2008.
, Cadherins are cell-to-cell adhesion molecules that play an important role in the establishment of adherent-type junctions by mediating calcium-dependent cellular interactions. The CDH1 gene encodes the transmembrane glycoprotein E-cadherin which is important in maintaining homophilic cell-cell adhesion in epithelial tissues. E-cadherin interacts with catenin proteins to maintain tissue architecture. Structural defects or loss of expression of E-cadherin have been reported as a common feature in several human cancer types.