Neuroepithelial tumors

Differential expression of E-cadherin gene in human neuroepithelial tumors

F. J. N. Motta, Valera, E. T., Lucio-Eterovic, A. K. B., Queiroz, R. G. P., Neder, L., Scrideli, C. A., Machado, H. R., Carlotti-Junior, C. G., Marie, S. K. N., and Tone, L. G., Differential expression of E-cadherin gene in human neuroepithelial tumors, vol. 7, pp. 295-304, 2008.

Cadherins are cell-to-cell adhesion molecules that play an important role in the establishment of adherent-type junctions by mediating calcium-dependent cellular interactions. The CDH1 gene encodes the transmembrane glycoprotein E-cadherin which is important in maintaining homophilic cell-cell adhesion in epithelial tissues. E-cadherin interacts with catenin proteins to maintain tissue architecture. Structural defects or loss of expression of E-cadherin have been reported as a common feature in several human cancer types.

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