NGR

Preparation and biological activity of a paclitaxel-single-walled carbon nanotube complex

X. D. Fu, Zhang, Y. Y., Wang, X. J., Shou, J. X., Zhang, Z. Z., and Song, L. J., Preparation and biological activity of a paclitaxel-single-walled carbon nanotube complex, vol. 13, pp. 1589-1603, 2014.

Single-walled carbon nanotubes (SWCNTs) have unique transmembrane abilities. The huge superficial area and abundance of π electrons confer SWCNTs perfect absorptive capability toward proteins, nucleates, and many drugs. These characteristics make SWCNTs a new and efficient drug carrier. The purpose of this study was to disperse SWCNTs in water and have paclitaxel absorbed onto them in order to construct an asparagine-glycine-arginine (NGR)-SWCNT-Paclitaxel complex as a targeting nanoparticle system.

Effects of curcumin on hippocampal expression of NgR and axonal regeneration in Aβ-induced cognitive disorder rats

H. L. Yin, Wang, Y. L., Li, J. F., Han, B., Zhang, X. X., Wang, Y. T., and Geng, S., Effects of curcumin on hippocampal expression of NgR and axonal regeneration in Aβ-induced cognitive disorder rats, vol. 13, pp. 2039-2047, 2014.

Curcumin has been widely used for the prevention and treatment of Alzheimer's disease (AD), but its mechanism is still not clear. Inhibitory factors of axonal regeneration have been shown to cause a series of pathophysiological changes in the early period of AD. In this study, the co-receptor (Nogo receptor; NgR) of three axonal growth-inhibitory proteins was examined, and effects of curcumin on spatial learning and memory abilities and hippocampal axonal growth were investigated in amyloid β-protein (Aβ)1-40-induced AD rats.

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