Nitrotyrosine

Effect of MPO/H2O2/NO- system on nitric oxide-mediated modification of TTR amyloid and serum TTR in FAP ATTR Val30Met patients

J. P. Liu, Wang, Q. Y., Zheng, F., Lu, J. H., Ge, P., Gu, Y. J., and Sun, X. G., Effect of MPO/H2O2/NO- system on nitric oxide-mediated modification of TTR amyloid and serum TTR in FAP ATTR Val30Met patients, vol. 13, pp. 2368-2376, 2014.

Amyloid deposits consist of protein fibrils and amorphous material, and this deposition is related to oxidative stress. Previously, we demonstrated the presence of high-density lipoproteins and/or lipids in amyloid deposits of familial amyloid polyneuropathy patients. In this study, the presence of myeloperoxidase (MPO) in amyloid deposits was demonstrated using immunohistochemical staining. In contrast, normal surrounding tissues were consistently negative for MPO.

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