In vitro effect of dexmedetomidine on the respiratory burst of neutrophils
“In vitro effect of dexmedetomidine on the respiratory burst of neutrophils”, vol. 15, p. -, 2016.,
The immunosuppressive effects of dexmedetomidine, a highly selective and widely used a2-adrenoceptor agonist for sedation, analgesia, and stress management, are investigated in vitro. In the present study, the respiratory burst of human neutrophils separated from venous blood was evaluated with dexmedetomidine treatment after Escherichia coli stimulation. The effects of five concentrations of dexmedetomidine (1, 5, 10, 50, 100 μg/mL) were evaluated by rhodamine in a flow cytometer.