NOD2/CARD15 variants in Malaysian patients with sporadic colorectal cancer
“NOD2/CARD15 variants in Malaysian patients with sporadic colorectal cancer”, vol. 13, pp. 7079-7085, 2014.,
Colorectal cancer (CRC) is one of the most common types of cancer in both developed and developing countries. This disease is triggered by and progresses via the sequential accumulation of multiple genetic alterations. In addition, the interaction between low-penetrance genes and environmental factors can also increase the risk of developing CRC. Since inflammatory bowel diseases (IBDs) are one of the predisposing factors for CRC, IBD-related genes might, to a certain extent, be associated with cancer initiation.