Nonalcoholic fatty liver disease

Role of APN and TNF-α in type 2 diabetes mellitus complicated by nonalcoholic fatty liver disease

X. Lin, Zhang, Z., Chen, J. M., Xu, Y. Y., Ye, H. R., Cui, J., Fang, Y., Jin, Y., Zhu, D. R., and Yuan, L., “Role of APN and TNF-α in type 2 diabetes mellitus complicated by nonalcoholic fatty liver disease”, vol. 14, pp. 2940-2946, 2015.

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease caused by non-excessive alcohol consumption and is the most common cause of elevated levels of serum liver enzymes. We examined changes in adiponectin (APN) and tumor necrosis factor-α (TNF-α) in type 2 diabetes mellitus (T2DM) complicated by NAFLD and their relationships with insulin resistance (IR). Forty-two T2DM, 39 NAFLD, and 45 T2DM complicated with NAFLD (complicated group) patients were enrolled in this study.

Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis

C. P. Li, Li, J. H., He, S. Y., Li, P., and Zhong, X. L., “Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis”, vol. 13, pp. 3991-3999, 2014.

The aim of this study was to investigate the roles of Fas/FasL, Bcl-2/Bax, and Caspase-8 mRNA expressions in nonalcoholic fatty liver disease (NAFLD). The apoptosis percentage was measured by flow cytometry, the immunohistochemical assay was performed for the determination of Fas, FasL, Bcl-2, and Bax expressions, and a real-time polymerase chain reaction (PCR) assay was performed to detect Caspase-8 mRNA expression.

Large-scale analysis of factors influencing nonalcoholic fatty liver disease and its relationship with liver enzymes

W. R. Bi, Yang, C. Q., Shi, Q., Xu, Y., Cao, C. P., Ling, J., and Wang, X. Y., “Large-scale analysis of factors influencing nonalcoholic fatty liver disease and its relationship with liver enzymes”, vol. 13, pp. 5880-5891, 2014.

Serum liver enzyme levels are often used effectively for the evaluation of nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the associations between serum liver enzyme levels and risks for NAFLD in over 8000 cases in a large-scale analysis. A cross-sectional survey with multiple stages and random samplings was performed from May 2007 to May 2009 on 8102 workers at Tongji University. A questionnaire was given, assessments of physical measurements, plasma glucose, lipid profiles, and liver enzymes were made, and real-time liver ultrasounds conducted.

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