Nonsynonymous single-nucleotide polymorphisms

Exploration of association between EPHX1 and chronic obstructive pulmonary disease on the basis of combined data mining

L. An, Xia, H., Zhou, P., Hua, L., An, L., Xia, H., Zhou, P., Hua, L., An, L., Xia, H., Zhou, P., and Hua, L., Exploration of association between EPHX1 and chronic obstructive pulmonary disease on the basis of combined data mining, vol. 15, p. -, 2016.

Chronic obstructive pulmonary disease (COPD) is an important respiratory disease with high mortality. Although smoking is the major environmental risk factor for the development of COPD, only 10% of heavy smokers develop symptomatic disease, suggesting association between genetic susceptibilities and environmental influences. In recent years, as one of the most widely studied genes including tests for associations between a genetic variant and COPD, epoxide hydrolase 1 (EPHX1) was found to be involved in the metabolism of tobacco smoke, an important risk factor of COPD.

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