Nuclear factor-kB

Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer

L. P. Chen, Cai, P. S., and Liang, H. B., Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer, vol. 14, pp. 8273-8282, 2015.

Nuclear factor-κB (NF-κB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-κB gene family) is associated with increased risk of various cancers. However, only one study has reported that rs28362491 is significantly associated with ovarian cancer.

Acanthopanax senticosus attenuates inflammation in lipopolysaccharide-induced acute lung injury by inhibiting the NF-κB pathway

X. J. Fei, Zhu, L. L., Xia, L. M., Peng, W. B., and Wang, Q., Acanthopanax senticosus attenuates inflammation in lipopolysaccharide-induced acute lung injury by inhibiting the NF-κB pathway, vol. 13, pp. 10537-10544, 2014.

The dried roots of the plant Acanthopanax senticosus (AS) are used in traditional Oriental medicine and reportedly possess anti-inflammatory properties in vitro. However, whether AS has the same anti-inflammatory effect in vivo and the underlying mechanisms of this action remain unknown.

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