Nuclear factor-kB

Pterostilbene as treatment for severe acute pancreatitis

Y. J. Lin, Ding, Y., Wu, J., Ning, B. T., Lin, Y. J., Ding, Y., Wu, J., and Ning, B. T., Pterostilbene as treatment for severe acute pancreatitis, vol. 15, p. -, 2016.

Acute pancreatitis (AP) has a fast onset and progression, which lead to an unfavorable prognosis. Therefore, the development of novel drugs for its treatment is critical. As a homologous derivative of resveratrol, pterostilbene exerts a variety of effects including anti-inflammatory, antioxidant, and antitumor effects. This study investigated the potential of pterostilbene for treatment of severe AP (SAP) and related mechanisms. Effects of pterostilbene were evaluated in a Wistar rat model of AP.

Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer

L. P. Chen, Cai, P. S., and Liang, H. B., Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer, vol. 14, pp. 8273-8282, 2015.

Nuclear factor-κB (NF-κB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-κB gene family) is associated with increased risk of various cancers. However, only one study has reported that rs28362491 is significantly associated with ovarian cancer.

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