Obstructive sleep apnea

Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea

Y. Zhang, Li, N. - F., Abulikemu, S., Zhang, D. - L., Wang, Y. - C., Kong, J. - Q., Nuer, G. - L., Yan, Z. - T., Li, H. - J., Zhang, J. - H., and Zhang, X. - Y., Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea, vol. 14, pp. 6733-6743, 2015.

Recent data have indicated that inflammation may have an important correlation with obstructive sleep apnea (OSA). Studies have indicated a relationship between OSA and TNF-α gene polymorphisms. Zinc finger protein 36 (ZFP36) regulates TNF-α mRNAs. However, ZFP36 gene polymorphisms have not been investigated in OSA. Therefore, we conducted the present case-control study to assess whether variances in ZFP36 gene polymorphisms account for differences in TNF-α levels in patients with moderate-to-severe OSA.

Gender difference in protein expression of vascular wall in mice exposed to chronic intermittent hypoxia: a preliminary study

Q. Y. Li, Feng, Y., Lin, Y. N., Li, M., Guo, Q., Gu, S. Y., Liu, J. L., Zhang, R. F., and Wan, H. Y., Gender difference in protein expression of vascular wall in mice exposed to chronic intermittent hypoxia: a preliminary study, vol. 13, pp. 8489-8501, 2014.

Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular diseases such as systemic arterial hypertension, ischemic heart disease, stroke, heart failure, atrial fibrillation, and cardiac sudden death. The pathogenesis of cardiovascular disease in OSA is thought to be induced primarily by chronic intermittent hypoxia (CIH), a specific pattern of change in oxygenation during sleep. However, the underlying mechanisms of CIH-induced vasculature injury and gender differences are not well documented.

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