Oncogene

Associations between clinical characteristics and oncogene expression in patients with non-small cell lung cancer

Y. Han, Yu, D. P., Zhou, S. J., Song, X. Y., Li, Y. S., Xiao, N., Liu, Z. D., Sun, X. J., Zhao, Q. Y., and Liu, S. K., Associations between clinical characteristics and oncogene expression in patients with non-small cell lung cancer, vol. 13, pp. 8913-8924, 2014.

More than 40 oncogenes associated with non-small cell lung cancer (NSCLC) have been identified with varied gene expression. The correlations between specific clinical characteristics and oncogene expression in NSCLC patients were examined. From October 2011 to September 2012, a total of 60 patients with NSCLC (male:female, 34:24; mean age, 59.5 ± 10.6 years; age range, 31-81 years) were diagnosed and evaluated for treatment with radical resection at a single facility.

Oncogene-induced transcriptional patterns in established cell lines as a model for in vitro analysis of tumor biology

Fde Paula Careta, Azevedo, B. Marcos Ver, Vianna, B. Alves, Paneto, G. Gaburro, Degasperi, I. Iester, Oyama, Mdo Carmo, Fagundes, V., Perrone, Â. Maria Spag, and Louro, I. Drumond, Oncogene-induced transcriptional patterns in established cell lines as a model for in vitro analysis of tumor biology, vol. 3, pp. 410-420, 2004.

Established cell lines have long been used for in vitro studies of tumor biology, enabling investigators to control growth conditions and to draw important conclusions about the oncogenic microenvironment. However, gene expression behavior in cultured cells may not always reflect the actual in vivo scenario, and analysis derived from such experiments should take into consideration the existing differences between the two environments.

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