Optic nerve

Functional analysis of differentially expressed genes associated with glaucoma from DNA microarray data

Y. Wu, Zang, W. D., and Jiang, W., Functional analysis of differentially expressed genes associated with glaucoma from DNA microarray data, vol. 13, pp. 9421-9428, 2014.

Microarray data of astrocytes extracted from the optic nerves of donors with and without glaucoma were analyzed to screen for differentially expressed genes (DEGs). Functional exploration with bioinformatic tools was then used to understand the roles of the identified DEGs in glaucoma. Microarray data were downloaded from the Gene Expression Omnibus (GEO) database, which contains 13 astrocyte samples, 6 from healthy subjects and 7 from patients suffering from glaucoma. Data were pre-processed, and DEGs were screened out using R software packages.

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