Osteoarthritis

Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model

X. Q. Chu, Wang, J. J., Dou, L. D., and Zhao, G., “Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model”, vol. 14, pp. 14207-14215, 2015.

The main pathological characteristic of osteoarthritis (OA) is cartilage damage. We explored cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3) changes during articular cartilage injury and repair. Rabbits were randomly divided into the following: a blank control group; groups M1, M2, and M3, in which breaking was performed for 2, 4, and 6 weeks, respectively; and groups L1, L2, and L3, in which breaking was discontinued for 2, 4, and 6 weeks, respectively, following a 4-week recovery period. There are 7 rabbits in each group.

Correlation between interleukin-6 expression in articular cartilage bone and osteoarthritis

X. Q. Qu, Wang, W. J., Tang, S. S., Liu, Y., and Wang, J. L., “Correlation between interleukin-6 expression in articular cartilage bone and osteoarthritis”, vol. 14, pp. 14189-14195, 2015.

This study aimed to investigate the expressional profile of interleukin-6 (IL-6) in articular cartilage bone of osteoarthritis (OA) patients and its correlation with OA. A total of 30 articular cartilage bone samples from knee OA patients, which were collected by knee arthroscopy or articular surgery, comprised the study group, and 30 samples of normal articular cartilage tissue comprised the control group.

High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis

G. Q. Zeng, Chen, A. B., Li, W., Song, J. H., and Gao, C. Y., “High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis”, vol. 14, pp. 14811-14822, 2015.

Our study examined the relationship between the expression of matrix metalloproteinases (MMP)-1, MMP-2, and MMP-9 proteins and the pathogenesis of osteoarthritis (OA). We employed rigorous inclusion and exclusion criteria in computer-based bibliographic databases to extract published studies relevant to this investigation. The STATA 12.0 software was used for the statistical analyses. A total of 1408 studies were initially searched, and 10 studies with 458 OA patients and 295 healthy controls were included in this meta-analysis.

Correlation of CD4+ CD25+ Foxp3+ Treg with the recovery of joint function after total knee replacement in rats with osteoarthritis

S. - Y. Guo, Ding, Y. - J., Li, L., Zhang, T., Zhang, Z. - Z., and Zhang, E. - S., “Correlation of CD4+ CD25+ Foxp3+ Treg with the recovery of joint function after total knee replacement in rats with osteoarthritis”, vol. 14, pp. 7290-7296, 2015.

In this study, we observed changes in CD4+ CD25+ Foxp3+ Treg expression in rats with osteoarthritis (OA) to explore the role that CD4+ CD25+ Foxp3+ Treg plays in the decline in the condition of OA rats. Thirty rats were randomly divided into 2 groups equally and OA was induced in rats in the model group by injection of papain and l-cysteine into the right knee joint.

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