Osteoporosis

Treatment of vertebral body compression fractures using percutaneous kyphoplasty guided by a combination of computed tomography and C-arm fluoroscopy with finger-touch guidance to determine the needle entry point

G. Y. Wang, Zhang, C. C., Ren, K., Zhang, P. P., Liu, C. H., Zheng, Z. A., Chen, Y., and Fang, R., “Treatment of vertebral body compression fractures using percutaneous kyphoplasty guided by a combination of computed tomography and C-arm fluoroscopy with finger-touch guidance to determine the needle entry point”, vol. 14, pp. 1546-1556, 2015.

This study aimed to evaluate the results and complications of image-guided percutaneous kyphoplasty (PKP) using computed tomography (CT) and C-arm fluoroscopy, with finger-touch guidance to determine the needle entry point. Of the 86 patients (106 PKP) examined, 56 were treated for osteoporotic vertebral compression fractures and 30 for vertebral tumors. All patients underwent image-guided treatment using CT and conventional fluoroscopy, with finger-touch identification of a puncture point within a small incision (1.5 to 2 cm).

Association of the g.27563G>A osteoprotegerin genetic polymorphism with bone mineral density in Chinese women

Y. P. Liu, Zhao, D. W., Wang, W. M., Wang, B. J., Zhang, Y., and Li, Z. G., “Association of the g.27563G>A osteoprotegerin genetic polymorphism with bone mineral density in Chinese women”, vol. 13, pp. 3560-3566, 2014.

Osteoporosis is a common multifactorial disease in postmenopausal women. This study aimed to investigate the association of the g.27563G>A osteoprotegerin (OPG) genetic polymorphism with bone mineral density (BMD) and osteoporosis. A case-control study was carried out with 435 osteoporosis postmenopausal women cases and 442 age-matched healthy controls. The BMD at the femoral neck hip, lumbar spine (L2-4), and total hip were assessed by Norland XR-46 dual-energy X-ray absorptiometry.

Association analysis between the OPG g.27667T>A genetic variant and bone mineral density in Chinese postmenopausal women

J. J. Zhao, Feng, D. H., Cheng, L., Lu, T., and Wang, L., “Association analysis between the OPG g.27667T>A genetic variant and bone mineral density in Chinese postmenopausal women”, vol. 13, pp. 7332-7338, 2014.

The purpose of this study was to investigate the association of the g.27667T>A genetic variant in the osteoprotegerin (OPG) gene with bone mineral density (BMD) and osteoporosis. A total of 393 primary osteoporosis subjects and 402 healthy controls were recruited. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were evaluated by Norland XR-46 dual-energy X-ray absorptiometry. The g.27667T>A genetic variant was genotyped using created restriction site-polymerase chain reaction.

BMP-2 promotes chondrogenesis of rat adipose-derived stem cells by using a lentiviral system

H. L. Fu, Diao, Z. Y., Shao, L., and Yang, D. P., “BMP-2 promotes chondrogenesis of rat adipose-derived stem cells by using a lentiviral system”, vol. 13, pp. 8620-8631, 2014.

Osteoporosis poses a major public health threat in aging societies. Adipose-derived stem cells (ADSCs) are multipotent adult stem cells that have the ability to yield mesenchymal stem cells, and have the potential to undergo osteogenesis and bone regeneration. Bone morphogenetic proteins (BMPs) have been demonstrated to upregulate bone gene expression after mechanical injury and to improve bone injury repair. This study aimed to produce BMP-2 expression in ADSCs by using lentiviral vectors. Subcutaneous adipose tissue from 4-week-old male Sprague-Dawley rats was used.

Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women

A. González-Mercado, Sánchez-López, J. Y., Regla-Nava, J. A., Gámez-Nava, J. I., González-López, L., Duran-Gonzalez, J., Celis, A., Perea-Díaz, F. J., Salazar-Páramo, M., and Ibarra, B., “Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women”, vol. 12, pp. 2755-2763, 2013.

We investigated associations between vitamin D receptor (VDR) gene polymorphisms, FokI T>C (rs2228570), BsmI G>A (rs1544410), ApaI G>T (rs7975232), and TaqI T>C (rs731236), with bone mineral density (BMD) in postmenopausal Mexican-Mestizo women. Three hundred and twenty postmenopausal women participated, who were classified according to World Health Organization criteria as non-osteoporotic (Non-OP; N = 88), osteopenic (Opn; N = 144), and osteoporotic (OP; N = 88).

Association between single nucleotide polymorphisms of the osteoprotegerin gene and postmenopausal osteoporosis in Chinese women

J. F. Song, Jing, Z. Z., Hu, W., and Su, Y. X., “Association between single nucleotide polymorphisms of the osteoprotegerin gene and postmenopausal osteoporosis in Chinese women”, vol. 12, pp. 3279-3285, 2013.

Osteoporosis is an important and common complex health problem, particularly in postmenopausal women. It is characterized by a reduction in bone mineral density (BMD) and a deterioration of bone microarchitecture with a consequent increase of fracture risk. The osteoprotegerin (OPG) gene is considered to play an important role in the pathogenesis of osteoporosis. We analyzed SNPs of the OPG gene and associations between these polymorphisms and BMD in 399 Chinese postmenopausal women.

Protein-protein interaction network and significant gene analysis of osteoporosis

X. M. Wu, Ma, X., Tang, C., Xie, K. N., Liu, J., Guo, W., Yan, Y. L., Shen, G. H., and Luo, E. P., “Protein-protein interaction network and significant gene analysis of osteoporosis”, vol. 12, pp. 4751-4759, 2013.

This study used DNA microarray data to identify differentially expressed genes of osteoporosis and provide useful information for treatments of the disease. We downloaded gene expression data of Osteoporosis GSE35956 from the Gene Expression Omnibus database, which included five normal and five osteoporosis samples. We then identified the differentially expressed genes between normal and disease samples using the R language software, and constructed the protein interaction network. DAVID was used to perform the biological process enrichment and KEGG pathway cluster analyses.

Lack of effect of bone morphogenetic protein 2 and 4 gene polymorphisms on bone density in postmenopausal Turkish women

Z. S. Özkan, Deveci, D., E. Önalan, E., and Yüce, H., “Lack of effect of bone morphogenetic protein 2 and 4 gene polymorphisms on bone density in postmenopausal Turkish women”, vol. 9, pp. 2311-2316, 2010.

We investigated the effect of bone morphogenetic protein 2 and 4 (BMP-2 and -4) gene polymorphisms on bone density in postmenopausal Turkish women with osteoporosis. The frequency of single-nucleotide polymorphisms (SNPs) of BMP-2 and -4 genes was analyzed in 101 osteoporotic-postmenopausal women and 52 postmenopausal women with positive bone mineral density scores. We evaluated the frequency of the thymine→cytosine nucleotide variation at position 538 for BMP-4 and the transposition of adenine→thymine at codon 190 for BMP-2, with PCR.

Association of serum sex steroid levels and bone mineral density with CYP17 and CYP19 gene polymorphisms in postmenopausal women in Turkey

M. B. Yilmaz, Pazarbasi, A., Guzel, A. I., Kocaturk-Sel, S., Kasap, H., Kasap, M., Urunsak, I. F., Basaran, S., Alptekin, D., and Demirhan, O., “Association of serum sex steroid levels and bone mineral density with CYP17 and CYP19 gene polymorphisms in postmenopausal women in Turkey”, vol. 10, pp. 1999-2008, 2011.

Many clinical conditions, including osteoporosis, are associated with serum levels of sex steroids. Enzymes that regulate rate-limiting steps of steroidogenic pathways, such as CYP17 and CYP19, are also regarded as significant factors that may cause the development of these conditions.

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