Ovarian cancer

Prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis

Y. Y. Shi, Jiang, H., Shi, Y. Y., and Jiang, H., “Prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis”, vol. 15, p. -, 2016.

This meta-analysis study aimed to investigate the correlation between CD44-positive cancer stem cells (CSCs) and clinicopathological features and its effect on the survival of ovarian cancer patients. A comprehensive literature search in the electronic databases, including PubMed, EMBASE, and Wanfang (up to December 1, 2015), was conducted. Publications assessing the clinical or prognostic significance of CD44 expression in ovarian cancer were identified and reviewed until December 1, 2015.

miR-146a and miR-196a2 polymorphisms in ovarian cancer risk

X. C. Sun, Zhang, A. C., Tong, L. L., Wang, K., Wang, X., Sun, Z. Q., Zhang, H. Y., Sun, X. C., Zhang, A. C., Tong, L. L., Wang, K., Wang, X., Sun, Z. Q., and Zhang, H. Y., “miR-146a and miR-196a2 polymorphisms in ovarian cancer risk”, vol. 15, p. -, 2016.

We investigated the relationship between miR-146a and miR-196a2 genetic polymorphisms and development of ovarian cancer in a Chinese population. A total of 134 patients and 227 control subjects were involved in our study between January 2012 and October 2014 from China-Japan Union Hospital of Jilin University. Genotyping of miR-146a and miR-196a2 was accomplished by polymerase chain reaction coupled with restriction fragment length polymorphism analysis.

Effects of the balance between type 1 and type 2 T helper cells on ovarian cancer

C. J. Hao, Li, J., Liu, P., Li, X. L., Hu, Y. Q., Sun, J. C., Wei, Y., Hao, C. J., Li, J., Liu, P., Li, X. L., Hu, Y. Q., Sun, J. C., and Wei, Y., “Effects of the balance between type 1 and type 2 T helper cells on ovarian cancer”, vol. 15, p. -, 2016.

The balance between type 1 and type 2 T helper cells (the Th1-Th2 balance) is closely correlated with cancer, but the correlation in ovarian cancer remains unconfirmed. We investigated the Th1-Th2 balance for the diagnosis, treatment, and prognostic evaluation of ovarian cancer. Fifty healthy subjects and 50 ovarian cancer patients were recruited. The levels of various cytokines were determined in sera and ovarian cancer tissues using a Th1-Th2 human cytokine array.

Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer

W. Pan and Liao, H., “Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer”, vol. 14, pp. 16813-16818, 2015.

The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, and WanFang Data. The literature was screened based on inclusion and exclusion criteria.

Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer

L. P. Chen, Cai, P. S., and Liang, H. B., “Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer”, vol. 14, pp. 8273-8282, 2015.

Nuclear factor-κB (NF-κB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-κB gene family) is associated with increased risk of various cancers. However, only one study has reported that rs28362491 is significantly associated with ovarian cancer.

MTHFR A1298C polymorphism and ovarian cancer risk: a meta-analysis

X. Y. Shi and Shen, Q., “MTHFR A1298C polymorphism and ovarian cancer risk: a meta-analysis”, vol. 14, pp. 8211-8218, 2015.

Numerous studies have evaluated the association between the MTHFR A1298C polymorphism and ovarian cancer risk. However, the specific association is still controversial. Therefore, we performed the present meta-analysis. A systematic literature search of PubMed and Embase databases was undertaken in August 2014, and the reference lists of articles were retrieved. ORs with their 95%CI were calculated to evaluate the strength of the association. Meta-analysis was performed using the STATA version 12.0 software package and publication bias was investigated by Begg’s funnel plot.

Arg188His polymorphism in the XRCC2 gene and the risk of ovarian cancer: a meta-analysis

M. Zhai, Wang, Y., and Jiang, M. F., “Arg188His polymorphism in the XRCC2 gene and the risk of ovarian cancer: a meta-analysis”, vol. 14, pp. 10808-10815, 2015.

Numerous studies have evaluated the association between the Arg188His polymorphism of the X-ray repair cross-complementing group 2 (XRCC2) gene and ovarian cancer risk. However, the specific association is still controversial. This meta-analysis was therefore designed to clarify these controversies. Relevant case-control studies were enrolled in the meta-analysis. Quality evaluation of the included studies was conducted by two physicians. Statistical analyses were carried out using the Stata 12.0 software for meta-analysis.

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