Ovarian cancer cells

Tumor-associated fibroblast-conditioned medium promotes tumor cell proliferation and angiogenesis

L. N. Xu, Xu, B. N., Cai, J., Yang, J. B., and Lin, N., Tumor-associated fibroblast-conditioned medium promotes tumor cell proliferation and angiogenesis, vol. 12, pp. 5863-5871, 2013.

This study aimed to explore how tumor-associated fibroblasts (TAFs) promote the proliferation and angiogenesis of tumor cells via the paracrine mechanism in vitro. Conditioned media (CM) of ovarian TAFs and normal fibroblasts (NFs) were collected. Ovarian cancer cells (OCCs) were treated with 2 mL TAFs-CM and NFs-CM in experimental and control groups, respectively; 20 mM SB431512, a specific small molecule inhibitor of transforming growth factor-β (TGF-β), was added in the experimental group as the intervention group. The cell cycle was determined in each group.

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