Genetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma
, “Genetic variability of genes involved in DNA repair influence treatment outcome in osteosarcoma”, vol. 14, pp. 11652-11657, 2015.
We conducted a perspective study to investigate the role of ERCC1 (rs11615), ERCC2 (rs13181 and rs1799793), ERCC4 (rs1800067), and ERCC5 (rs17655) in NER pathway in the prognosis of osteosarcoma patients. In total, 146 osteosarcoma patients were recruited between 2008 and 2013. ERCC1 rs11615, ERCC2 rs13181 and rs1799793, ERCC4 rs1800067, and ERCC5 rs17655 gene polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism assay.
