Oxidative stress

Effects and mechanism of lipoic acid on beta-amyloid-intoxicated C6 glioma cells

Z. G. Xing, Yu, G. D., Qin, L., Jiang, F., and Zhao, W. H., Effects and mechanism of lipoic acid on beta-amyloid-intoxicated C6 glioma cells, vol. 14, pp. 13880-13888, 2015.

β-amyloid peptides (Aβs) can exert neurotoxic effects through induction of oxidative damage, whereas lipoic acid (LA), a powerful antioxidant, can alleviate oxidative damage. In this study, we explored the effect and mechanism of action of LA on beta-amyloid-intoxicated C6 glioma cells. Cells were randomly divided into three groups: control (vehicle), Aβ, and LA + Aβ. The LA + Aβ group was treated with LA for 2 h, then both the Aβ-only and the LA + Aβ groups were incubated with 25 μM Aβ for 24 h. Cell viability was measured by the MTT method.

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