Oxidative stress

XPD and hOGG1 gene polymorphisms in reperfusion oxidative stress

O. İsbir, Gormus, U., Ergen, H. A., Cakmakoglu, B., Kahraman, Ö. T., and Baykan, N., XPD and hOGG1 gene polymorphisms in reperfusion oxidative stress, vol. 10, pp. 3157-3162, 2011.

Knee replacement surgery is an ischemia/reperfusion model, as it uses tourniquet applied to the knee area to stop the blood flow during the operation. Fifty patients that were undergoing elective arthroscopic knee surgery were included in our study. Human 8-oxoguanine glycosylase 1 (hOGG1) is an enzyme to repair specific DNA lesions and a good marker of hydroxyl radical damage to DNA. XPD is another DNA repair gene. We investigated the effect of hOGG1 (Ser326Cys) and XPD (Lys751Gln) polymorphisms on the oxidative stress level after reperfusion.

Behavior and viability of spontaneous oxidative stress-resistant Lactococcus lactis mutants in experimental fermented milk processing

M. N. Oliveira, Almeida, K. E., Damin, M. R., Rochat, T., Gratadoux, J. - J., Miyoshi, A., Langella, P., and Azevedo, V., Behavior and viability of spontaneous oxidative stress-resistant Lactococcus lactis mutants in experimental fermented milk processing, vol. 8, pp. 840-847, 2009.

Previously, we isolated two strains of spontaneous oxidative (SpOx2 and SpOx3) stress mutants of Lactococcus lactis subsp cremoris. Herein, we compared these mutants to a parental wild-type strain (J60011) and a commercial starter in experimental fermented milk production. Total solid contents of milk and fermen­tation temperature both affected the acidification profile of the spon­taneous oxidative stress-resistant L. lactis mutants during fermented milk production.

Lipid peroxidation and antioxidant capacity of G6PD-deficient patients with A-(202G>A) mutation

L. S. Ondei, Silveira, L. M., Leite, A. A., Souza, D. R. S., Pinhel, M. A. S., Percário, S., O. Júnior, R., and Bonini-Domingos, C. R., Lipid peroxidation and antioxidant capacity of G6PD-deficient patients with A-(202G>A) mutation, vol. 8, pp. 1345-1351, 2009.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy in which reduced NADPH concentrations are not maintained, resulting in oxidative damage. We evaluated G6PD activity, oxidative stress levels and Trolox equivalent antioxidant capacity in individuals with the A-(202G>A) mutation for G6PD deficiency. Five hundred and forty-four peripheral blood samples were screened for G6PD deficiency; we also analyzed lipid peroxidation products measured as thiobarbituric acid reactive species and Trolox equivalent antioxidant capacity.

Oxidative stress response in Paracoccidioides brasiliensis

É. G. Campos, Dantas, Ada Silva, Brigido, Mde Macedo, Brigido, Mde Macedo, Felipe, M. Sueli S., and Jesuino, R. Santos Amo, Oxidative stress response in Paracoccidioides brasiliensis, vol. 4, pp. 409-429, 2005.

Survival of pathogenic fungi inside human hosts depends on evasion from the host immune system and adaptation to the host environment. Among different insults that Paracoccidioides brasiliensis has to handle are reactive oxygen and nitrogen species produced by the human host cells, and by its own metabolism. Knowing how the parasite deals with reactive species is important to understand how it establishes infection and survives within humans. The initiative to describe the P.

Association among oxidized LDL levels, MnSOD, apolipoprotein E polymorphisms, and cardiovascular risk factors in a south Brazilian region population

M. G. V. Gottlieb, Schwanke, C. H. A., Santos, A. F. R., Jobim, P. F., da Cruz, I. B. M., and Müssel, D. P., Association among oxidized LDL levels, MnSOD, apolipoprotein E polymorphisms, and cardiovascular risk factors in a south Brazilian region population, vol. 4, pp. 691-703, 2005.

Oxidized LDL (ox-LDL) is involved in the initiation and progression of atherosclerosis. Many factors can affect the LDL oxidation such as oxidative stress. The present study tested whether ox-LDL levels would be associated with apolipoprotein E (APOE), manganese superoxide dismutase (MnSOD) Ala16Val polymorphisms, and classic cardiovascular risk factors.

Further phenotypic characterization of pso mutants of Saccharomyces cerevisiae with respect to DNA repair and response to oxidative stress

C. Pungartnik, Picada, J., Brendel, M., and Henriques, J. A. P., Further phenotypic characterization of pso mutants of Saccharomyces cerevisiae with respect to DNA repair and response to oxidative stress, vol. 1, pp. 79-89, 2002.

The sensitivity responses of seven pso mutants of Saccharomyces cerevisiae towards the mutagens N-nitrosodiethylamine (NDEA), 1,2:7,8-diepoxyoctane (DEO), and 8-hydroxyquinoline (8HQ) further substantiated their allocation into two distinct groups: genes PSO1 (allelic to REV3), PSO2 (SNM1), PSO4 (PRP19), and PSO5 (RAD16) constitute one group in that they are involved in repair of damaged DNA or in RNA processing whereas genes PSO6 (ERG3) and PSO7 (COX11) are

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