p14ARF

Mutational analysis of genes p14ARF, p15INK4b, p16INK4a, and PTEN in human nervous system tumors

L. O. Almeida, Custódio, A. C., Araújo, J. J., Rey, J. A., Almeida, J. R. W., Santos, M. J., Clara, C. A., and Casartelli, C., Mutational analysis of genes p14ARF, p15INK4b, p16INK4a, and PTEN in human nervous system tumors, vol. 7, pp. 451-459, 2008.

The cancer is one of the most common and severe problems in clinical medicine, and nervous system tumors represent about 2% of the types of cancer. The central role of the nervous system in the maintenance of vital activities and the functional consequences of the loss of neurons can explain how severe brain cancers are. The cell cycle is a highly complex process, with a wide number of regulatory proteins involved, and such proteins can suffer alterations that transform normal cells into malignant ones.

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