p53 codon 72

Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies

W. H. Ren, Jiang, D. K., Pei, Y., Wang, S. Q., Yang, X. M., and Yu, L., Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies, vol. 13, pp. 103-114, 2014.

Genetic factors have been shown to play a role in the development of head and neck cancers (HNCs). However, studies investigating the association between the TP53 Arg72Pro polymorphism and HNCs susceptibility have yielded conflicting results. Hence, we performed a meta-analysis of all eligible studies (up to January 1, 2012) to derive a more precise estimation of this association in order to increase understanding of the possible risk factors of HNCs. Twenty-seven case-control studies involving 3966 cases and 4387 controls were included in our analysis.

Association between p53 codon 72 polymorphisms and clinical outcome of nasopharyngeal carcinoma

M. L. Li, Dong, Y., Hao, Y. Z., Xu, N., Ning, F. L., Chen, S. S., and Yu, J. M., Association between p53 codon 72 polymorphisms and clinical outcome of nasopharyngeal carcinoma, vol. 13, pp. 10883-10890, 2014.

We conducted a cohort study to investigate whether polymorphisms in p53 at codon 72 are associated with tumor response and survival time of advanced nasopharyngeal carcinoma (NPC) patients treated with radiotherapy. The study population included 127 subjects with NPC who were enrolled at Binzhou Medical University between September 2008 and December 2009. Cox proportional hazard regression was used to assess the association between polymorphisms in the p53 gene and progression-free survival (PFS) and overall survival (OS) of NPC patients.

Meta-analysis of epidemiological studies of association of P53 codon 72 polymorphism with bladder cancer

D. B. Li, Wei, X., Jiang, L. H., Wang, Y., and Xu, F., Meta-analysis of epidemiological studies of association of P53 codon 72 polymorphism with bladder cancer, vol. 9, pp. 1599-1605, 2010.

Although there have been many studies investigating a possible association between p53 codon 72 polymorphism and risk of bladder cancer, the results have been inconsistent. We conducted a meta-analysis of six epidemiological studies, which included 597 bladder cancer cases and 731 controls. Patients with bladder cancer had a significantly lower frequency of Pro/Arg [odds ratio (OR) = 0.80, 95% confidence interval (CI) = 0.64-0.99], when compared to controls.

Meta-analysis demonstrates no association between p53 codon 72 polymorphism and prostate cancer risk

M. S. Li, Liu, J. L., Wu, Y., Wang, P., and Teng, H., Meta-analysis demonstrates no association between p53 codon 72 polymorphism and prostate cancer risk, vol. 10, pp. 2924-2933, 2011.

We examined whether p53 codon 72 polymorphism confers prostate cancer risk by conducting a meta-analysis. Two investigators independently searched the Pubmed, Embase and CBM databases. This meta-analysis was made of seven case-control studies, that included 892 prostate cancer cases and 1020 healthy controls.

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