Parkinson’s disease

Role of ADH2 and ALDH2 gene polymorphisms in the development of Parkinson's disease in a Chinese population

C. C. Zhao, Cai, H. B., Wang, H., Pan, S. Y., Zhao, C. C., Cai, H. B., Wang, H., and Pan, S. Y., Role of ADH2 and ALDH2 gene polymorphisms in the development of Parkinson's disease in a Chinese population, vol. 15, p. -, 2016.

In this study, we investigated the role of ADH2 Arg47His and ALDH2 Glu487Lys genetic polymorphisms in the development of Parkinson’s disease in a Chinese population. Between January 2013 and May 2014, 115 patients with Parkinson’s disease and 214 healthy controls were recruited in our study. Genotyping of ADH2 Arg47His and ALDH2 Glu487Lys polymorphisms was performed by the polymerase chain reaction-restriction fragment length polymorphism method.

Effect of siRNA-induced silencing of cellular prion protein on tyrosine hydroxylase expression in the substantia nigra of a rat model of Parkinson’s disease

X. Wang, Yang, H. A., Wang, X. N., Du, Y. F., Wang, X., Yang, H. A., Wang, X. N., and Du, Y. F., Effect of siRNA-induced silencing of cellular prion protein on tyrosine hydroxylase expression in the substantia nigra of a rat model of Parkinson’s disease, vol. 15, p. -, 2016.

The most significant pathological feature of Parkinson’s disease (PD) is the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra. Currently, available treatments for PD cannot prevent the loss of DA neurons. Tyrosine hydroxylase (TH) expressed in substantia nigra neurons catalyzes the conversion of tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which is the rate-limiting step of DA biosynthesis. Major reasons for PD occurrence include decreased TH activity in the substantia nigra and secondary DA suppression.

Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population

J. J. Liu, Wang, W., Meng, M., Liang, C. S., Zhang, J. W., Liu, J. J., Wang, W., Meng, M., Liang, C. S., and Zhang, J. W., Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population, vol. 15, p. -, 2016.

Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine, throughout November 2015.

Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population

J. J. Liu, Wang, W., Meng, M., Liang, C. S., and Zhang, J. W., Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population, vol. 15, p. -, 2016.

Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine, throughout November 2015.

Protective effects and mechanisms of Ndfipl on SH-SY5Y cell apoptosis in an in vitro Parkinson’s disease model

L. F. Xing, Guo, H. P., Wang, D. T., Sun, L. H., Pan, S. Y., Xing, L. F., Guo, H. P., Wang, D. T., Sun, L. H., Pan, S. Y., Xing, L. F., Guo, H. P., Wang, D. T., Sun, L. H., and Pan, S. Y., Protective effects and mechanisms of Ndfipl on SH-SY5Y cell apoptosis in an in vitro Parkinson’s disease model, vol. 15, p. -, 2016.

The aim of the current study was to examine the protective effects and mechanisms of Ndfipl on neurocytes in an experimental in vitro Parkinson’s disease model induced by MPP+. The cell model was developed with dominant negative expression and suppressed expression of Ndfipl by means of transient transfection of Ndfipl-dominant negative and -inhibitory vectors. In total, four different Ndfipl cell models were established. Different methods were used to analyze the cells.

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