Paternal genome

De novo DNA methylation of the paternal genome in 2-cell mouse embryos

X. S. Ma, Wang, X. G., Qin, L., Song, C. L., Lin, F., Song, J. M., Zhu, C. C., and Liu, H. L., De novo DNA methylation of the paternal genome in 2-cell mouse embryos, vol. 13, pp. 8632-8639, 2014.

The developmental dynamics of DNA methylation events have been well studied. Active demethylation of the paternal genome occurs in the zygote, passive demethylation occurs during cleavage stages, and de novo methylation occurs by the blastocyst stage. It is believed that the paternal genome has lower levels of methylation during early development than the maternal genome. However, in this study, we provide direct and indirect evidence of genome-wide de novo DNA methylation of the paternal genome after the first cell cycle in mouse embryos.

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