Pathway

Deep RNA sequencing elucidates microRNA-regulated molecular pathways in ischemic cardiomyopathy and nonischemic cardiomyopathy

X. Li, Liu, C. Y., Li, Y. S., Xu, J., Li, D. G., Han, D., Li, X., Liu, C. Y., Li, Y. S., Xu, J., Li, D. G., Han, D., Li, X., Liu, C. Y., Li, Y. S., Xu, J., Li, D. G., and Han, D., Deep RNA sequencing elucidates microRNA-regulated molecular pathways in ischemic cardiomyopathy and nonischemic cardiomyopathy, vol. 15, p. -, 2016.

Deregulation of cardiac miRNA gene-regulatory networks is a feature of different heart diseases, including ischemic (ICM) and nonischemic (NICM) cardiomyopathy. Here, based on the paired miRNA and mRNA expression profiles in ICM and NICM, we identified the differentially expressed miRNAs and mRNAs and the expression signatures distinguishing ICM/NICM from control samples. Furthermore, we constructed a functional miRNA network for each disease.

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