PBMCs

Up-regulation of Id1 in peripheral blood of psoriatic patients

C. Ronpirin, Achariyakul, M., Tencomnao, T., Wongpiyabovorn, J., and Chaicumpa, W., Up-regulation of Id1 in peripheral blood of psoriatic patients, vol. 9, pp. 2239-2247, 2010.

Although the precise causes of psoriasis are unclear, it is widely accepted that psoriasis is a disorder in which factors in the immune system, enzymes, and other biochemical substances that regulate skin cell division are impaired, leading to rapid proliferation of keratinocytes and incomplete keratinization. Expression of the helix-loop-helix transcription factor Id1 (inhibitor of differentiation/DNA binding), functioning as an inhibitor of differentiation, is known to increase in psoriatic skin.

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