Peripheral arterial occlusive disease

Expression of high-mobility group box protein 1 in diabetic foot atherogenesis

C. F. Tsao, Huang, W. T., Liu, T. T., Wang, P. W., Liou, C. W., Lin, T. K., Hsieh, C. J., and Weng, S. W., Expression of high-mobility group box protein 1 in diabetic foot atherogenesis, vol. 14, pp. 4521-4531, 2015.

The role of high mobility group box 1 (HMGB1) has been demonstrated in stroke and coronary artery disease but not in peripheral arterial occlusive disease (PAOD). The pathogenesis of HMGB1 in acute and chronic vascular injury is also not well understood. We hypothesized that HMGB1 induces inflammatory markers in diabetic PAOD patients. We studied 36 diabetic patients, including 29 patients with PAOD, who had undergone amputation for diabetic foot and 7 nondiabetic patients who had undergone amputation after traumatic injury.

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