Planaria

miR-71b regulation of insulin/IGF-1 signaling during starvation in planarians

Y. Y. Wu, Zhao, J. M., Liu, Q., Guo, Q., Liu, Z., Wang, X. X., Wang, C. Y., Li, R. Y., Zhang, Y. Z., and Zhang, S. T., miR-71b regulation of insulin/IGF-1 signaling during starvation in planarians, vol. 14, pp. 11905-11914, 2015.

Planarians, which have a large population of stem cells called neoblasts, are molecularly tractable model systems used in the study of regeneration. However, planarians have strong resistance to hunger and have developed growth arrest strategies. For example, they can change their size and undergo growth regression during starvation periods. The results of the current study show that the microRNA, miR-71b, and the insulin/IGF-1 signaling pathway have important functions in the development of starvation-induced planarians.

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