Polychlorinated biphenyls

Effect of polychlorinated biphenyls on oxidation stress in the liver of juvenile GIFT, Oreochromis niloticus

Y. Zheng, Qiu, L. P., Meng, S. L., Fan, L. M., Song, C., Li, D. D., Zhang, C., Chen, J. Z., Zheng, Y., Qiu, L. P., Meng, S. L., Fan, L. M., Song, C., Li, D. D., Zhang, C., and Chen, J. Z., Effect of polychlorinated biphenyls on oxidation stress in the liver of juvenile GIFT, Oreochromis niloticus, vol. 15, p. -, 2016.

The present study clearly showed that chronic exposure to polychlorinated biphenyls (PCBs) at environmentally relevant concentrations can damage juvenile tilapia livers by modulating antioxidant enzyme activities and gene transcription, which affects toxic bioaccumulation and histological congestion. The results suggest that PCBs caused a decrease in the activity of some hepatic antioxidative and biotransformation enzymes (SOD, CAT, GST, T-GSH, and MDA) in tilapia at 7 days, as well as transcriptional changes (sod, cat, and gst).

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