Polymorphism

Role of IL-10 gene polymorphisms in the development of acute pancreatitis

B. Z. Jiang, Tang, L., Xue, H., Liu, D. P., Jiang, B. Z., Tang, L., Xue, H., and Liu, D. P., Role of IL-10 gene polymorphisms in the development of acute pancreatitis, vol. 15, p. -, 2016.

Recent studies have suggested that chemokines contribute to the initiation and development of acute pancreatitis. We evaluated the relationship between IL-10 gene polymorphisms (-1082A/G and -819T/C) and development of acute pancreatitis in the Chinese population, in order to provide data for screening high-risk Chinese individuals. In total, 182 patients with confirmed cases of acute pancreatitis and 262 control subjects were recruited from the Shaanxi Provincial People’s Hospital between April 2012 and December 2014.

Identification of trends in scientific publications related to genetic polymorphisms in gestational diabetes mellitus

J. S. Gomes, Minasi, L. B., da Cruz, A. D., Rodrigues, F. M., Gomes, J. S., Minasi, L. B., da Cruz, A. D., and Rodrigues, F. M., Identification of trends in scientific publications related to genetic polymorphisms in gestational diabetes mellitus, vol. 15, p. -, 2016.

Gestational diabetes is a genetic multifactorial systemic disease that has been extensively studied. Consequently, there is a large volume of scientific literature pertaining to genes associated with gestational diabetes. The aim of this study was to characterize the main trends in scientific publications focusing on the associations between genetic polymorphisms and gestational diabetes mellitus (GDM).

Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population

D. H. Ma, Xu, Q. Y., Liu, Y., Zhai, Q. Q., Guo, M. H., Ma, D. H., Xu, Q. Y., Liu, Y., Zhai, Q. Q., and Guo, M. H., Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population, vol. 15, p. -, 2016.

In this study, we investigated the association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples by polymerase chain reaction-restriction fragment length polymorphism. The results were then statistically analyzed using SPSS 17.0.

Association between a microRNA-214 binding site polymorphism in the methylenetetrahydrofolate reductase gene and esophageal squamous cell carcinoma

G. R. Shen, Li, W. Z., Liu, Y. C., Li, X. P., Yuan, H. Y., Shen, G. R., Li, W. Z., Liu, Y. C., Li, X. P., and Yuan, H. Y., Association between a microRNA-214 binding site polymorphism in the methylenetetrahydrofolate reductase gene and esophageal squamous cell carcinoma, vol. 15, p. -, 2016.

MicroRNAs (miRNAs) are key regulators of gene expression and play an important role in the development and progression of various diseases including esophageal squamous cell carcinoma (ESCC). In this study, we determined whether a polymorphism at the miR-214 binding site in the 3'-untranslated region (3'-UTR) of the methylenetetrahydrofolate reductase gene (MTHFR) is associated with susceptibility to ESCC. A total of 448 ESCC cases and 460 gender- and age-matched subjects were recruited for the study.

Role and diagnostic value of gene variants in assessing the risk of chronic obstructive pulmonary disease

Z. P. Yan, Tong, X., Liu, S. T., Ma, Y., Peng, S. F., Yang, X., Fan, H., Yan, Z. P., Tong, X., Liu, S. T., Ma, Y., Peng, S. F., Yang, X., and Fan, H., Role and diagnostic value of gene variants in assessing the risk of chronic obstructive pulmonary disease, vol. 15, p. -, 2016.

Meta-analyses have revealed many positive associations between gene variants and susceptibility to chronic obstructive pulmonary disease (COPD). However, some of those positive results may be false positives. Therefore, we investigated the genetic polymorphisms associated with COPD risk and determined their diagnostic value.

Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer

J. Y. Gu, Tu, L., Gu, J. Y., and Tu, L., Investigating the role of polymorphisms in miR-146a, -149, and -196a2 in the development of gastric cancer, vol. 15, p. -, 2016.

Here, we performed a case-control study to investigate the role of miR-146a, miR-149, and miR-196a2 polymorphisms in the development of gastric cancer using a hospital-based case-control design. A total of 186 gastric cancer patients and 186 control subjects were enrolled from Ren Ji Hospital between January 2012 and October 2014. MicroRNAs miR-146a, miR-149, and miR-196a2 were genotyped by polymerase chain reaction coupled with restriction fragment length polymorphism.

Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population

L. M. Qin, Qin, G. M., Shi, X. H., Wang, A. L., Zuo, H., Qin, L. M., Qin, G. M., Shi, X. H., Wang, A. L., and Zuo, H., Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population, vol. 15, p. -, 2016.

We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism.

ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population

X. Gao, Tang, Y. J., Zhang, G. F., Yu, L., Qi, S. T., Gao, X., Tang, Y. J., Zhang, G. F., Yu, L., and Qi, S. T., ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population, vol. 15, p. -, 2016.

We conducted a case-control study to investigate the role of ERCC2 rs13181 polymorphism in glioma development. A total of 165 patients who were histopathologically diagnosed to have gliomas and 330 controls were collected at Jiujiang First People’s Hospital between July 2012 and June 2014. The ERCC2 rs13181 polymorphism was analyzed using a polymerase chain reaction -restriction fragment length polymorphism assay.

Myoglobin A79G polymorphism association with exercise-induced skeletal muscle damage

T. Cui, Jiang, M. S., Cui, T., and Jiang, M. S., Myoglobin A79G polymorphism association with exercise-induced skeletal muscle damage, vol. 15, p. -, 2016.

We assessed the role of A79G, a polymorphism of the myoglobin gene (MB), in susceptibility to exercise-induced skeletal muscle damage. Between January 2012 and December 2014, a total of 166 cases with exercise-induced skeletal muscle damage and 166 controls were recruited into our study. Genotyping of MB A79G was carried out using polymerase chain reaction coupled with restriction fragment length polymorphism.

First genetic linkage map for the mud crab (Scylla paramamosain) constructed using microsatellite and AFLP markers

H. Y. Ma, Li, S. J., Feng, N. N., Ma, C. Y., Wang, W., Chen, W., Ma, L. B., Ma, H. Y., Li, S. J., Feng, N. N., Ma, C. Y., Wang, W., Chen, W., and Ma, L. B., First genetic linkage map for the mud crab (Scylla paramamosain) constructed using microsatellite and AFLP markers, vol. 15, p. -, 2016.

The mud crab (Scylla paramamosain) is of economic importance for the fisheries and aquaculture industry in China. In this study, we constructed the first genetic linkage map for this species using microsatellite and amplified fragment length polymorphism (AFLP) markers. The map consisted of 65 linkage groups, including 34 triplets and 9 doublets. A total of 212 molecular markers were mapped, including 60 microsatellites and 152 AFLP markers. The linkage groups ranged from 7 to 102.5 cM and covered 2746.4 cM in length.

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