Polymorphism

Lack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population

J. J. Lu, Zhang, H. Q., Mai, P., Ma, X., Chen, X., Yang, Y. X., Zhang, L. P., Lu, J. J., Zhang, H. Q., Mai, P., Ma, X., Chen, X., Yang, Y. X., and Zhang, L. P., Lack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population, vol. 15, p. -, 2016.

We conducted a case-control study to assess the association between single nucleotide polymorphisms in the ERCC5 promoter (rs2094258 and rs751402) and development of gastric cancer in a Chinese population. This investigation included 184 patients with pathologically diagnosed gastric cancer and 206 healthy subjects recruited between October 2012 and December 2014. The genotyping of ERCC5 rs2094258 and rs751402 variants was performed by polymerase chain reaction coupled with restriction fragment length polymorphism.

IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population

S. X. Yang, Chen, F., Zhang, J. W., Sun, Z. Q., Chen, B. P., Yang, S. X., Chen, F., Zhang, J. W., Sun, Z. Q., and Chen, B. P., IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population, vol. 15, p. -, 2016.

IL-16 plays an important role in affect the secretion of tumor-related inflammatory cytokines. We aimed to assess the role of interleukin-16 (IL-16) rs4778889 T/C and rs11556218 T/G polymorphisms in the occurrence of renal cell cancer (RCC). This study is composed of 274 RCC patients and 274 control subjects. Genotyping of polymorphisms was performed using polymerase chain reaction combined with restriction fragment length polymorphism analysis. All statistical analysis was carried out by the SPSS statistical software package, version 16.0 (SPSS Inc., Chicago, IL, USA).

Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk

J. Ren, He, B. Z., Zhang, T. S., Lu, S. P., Yan, T., Ren, J., He, B. Z., Zhang, T. S., Lu, S. P., and Yan, T., Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk, vol. 15, p. -, 2016.

The aim of this meta-analysis was to assess the association between a polymorphism (-3860 G > A) in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer susceptibility. Relevant studies were retrieved from the PubMed and EMBase databases, and additionally evaluated for conformance with the inclusion criteria. The odds ratios (ORs) and their 95% confidence intervals (95%CIs) in all selected studies were used to assess the relationship between the CYP1A2 -3860 G > A polymorphism and lung cancer risk. The data was pooled using Stata v.11.

Association between ERCC5 gene polymorphisms and gastric cancer risk

B. W. Guo, Yang, L., Zhao, R., Hao, S. Z., Guo, B. W., Yang, L., Zhao, R., and Hao, S. Z., Association between ERCC5 gene polymorphisms and gastric cancer risk, vol. 15, p. -, 2016.

We investigate the role of ERCC5 gene polymorphisms (rs17655 and rs751402) in the development of gastric cancer in a Chinese population. A total of 142 gastric cancer patients whose diagnoses were confirmed by pathology, and 274 control subjects were recruited from Tangshan Gongren Hospital between March 2013 and March 2015. Genotyping of ERCC5 rs17655 and rs751402 polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism.

Interleukin-6 (IL-6) -174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population

L. Mao, Geng, G. Y., Han, W. J., Zhao, M. H., Wu, L., Liu, H. L., Mao, L., Geng, G. Y., Han, W. J., Zhao, M. H., Wu, L., and Liu, H. L., Interleukin-6 (IL-6) -174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population, vol. 15, p. -, 2016.

To investigate the role of IL-6 polymorphism (-174G/C and -572C/G) in the development of coronary artery disease (CAD), CAD patients (224) and control subjects (260) were recruited between January 2012 and December 2014. Genotyping at IL-6 -174G/C and -572C/G was conducted via polymerase chain reaction coupled to restriction fragment length polymorphism. Results indicated that several disease risk factors were significantly higher in CAD patients as compared to the control subjects.

Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis

M. Kuang, Xu, W., Cao, C. X., Shen, L. L., Chang, J., Zhang, X. L., Chen, J. F., Tang, C. J., Kuang, M., Xu, W., Cao, C. X., Shen, L. L., Chang, J., Zhang, X. L., Chen, J. F., and Tang, C. J., Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis, vol. 15, p. -, 2016.

Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this meta-analysis was conducted to obtain a comprehensive estimation of this association. A total of 20,615 cases and 20,481 controls from thirty-six case-control trials were extracted from an online literature survey.

Association of vitamin D receptor gene polymorphisms with end-stage renal disease and the development of high-turnover renal osteodystrophy in a Chinese population

L. Y. Wang, Zhang, P., Wang, H. F., Qin, Z. W., Wei, K. B., Lv, X. A., Wang, L. Y., Zhang, P., Wang, H. F., Qin, Z. W., Wei, K. B., and Lv, X. A., Association of vitamin D receptor gene polymorphisms with end-stage renal disease and the development of high-turnover renal osteodystrophy in a Chinese population, vol. 15, p. -, 2016.

Two single nucleotide polymorphisms (SNPs; TaqI and ApaI) in the vitamin D receptor (VDR) gene have been identified as risk factors for the progression of end-stage renal disease (ESRD). The purpose of our study was to confirm the reported association of these two SNPs with ESRD risk and progression of renal osteodystrophy in a Chinese Han population. A total of 452 ESRD patients and 904 matched-pair controls (based on age, gender, and body mass index) were included.

Association between matrix metallopeptidase 1 and type 2 diabetes mellitus coexisting with coronary heart disease in a Han Chinese population

Y. Z. Ma, Jiang, Q. Y., Kong, D. Q., Ma, Y. Z., Jiang, Q. Y., and Kong, D. Q., Association between matrix metallopeptidase 1 and type 2 diabetes mellitus coexisting with coronary heart disease in a Han Chinese population, vol. 15, p. -, 2016.

Matrix metallopeptidase 1 (MMP-1) has been reported to be involved in the coexistence of type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). We sought to examine the association between the MMP-1 gene polymorphism and coexistence of T2DM and CHD in a Han Chinese population. We extracted genomic DNA from the peripheral blood of 794 subjects, including 378 patients with coexisting T2DM and CHD and 416 healthy controls.

Meta-analysis of the correlation between the TNF-α308G/A polymorphism and polycystic ovary syndrome

X. B. Liu, Deng, X. H., Zhou, B., Zhang, L., Niu, X. M., Liu, X. B., Deng, X. H., Zhou, B., Zhang, L., and Niu, X. M., Meta-analysis of the correlation between the TNF-α308G/A polymorphism and polycystic ovary syndrome, vol. 15, p. -, 2016.

Previous studies have suggested that the tumor necrosis factor alpha (TNF-α) gene 308G/A polymorphism may be associated with polycystic ovary syndrome (PCOS) risk. However, this relationship is controversial. The present meta-analysis aimed to evaluate the correlation between the TNF-α308G/A polymorphism and susceptibility to PCOS. A systematic electronic search of PubMed and Embase databases was conducted using specific inclusion criteria.

Association between XPG gene polymorphisms and development of gastric cancer risk in a Chinese population

Y. B. Feng, Fan, D. Q., Yu, J., Bie, Y. K., Feng, Y. B., Fan, D. Q., Yu, J., and Bie, Y. K., Association between XPG gene polymorphisms and development of gastric cancer risk in a Chinese population, vol. 15, p. -, 2016.

We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene (rs2094258, rs751402 and rs17655) in the development of gastric cancer in a Chinese population. Between January 2012 and December 2014, samples from a total of 177 patients with gastric cancer and 237 control subjects were collected from the Ankang City Central Hospital.

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