Polymorphism

High polymorphism at microsatellite loci in the Chinese donkey

R. F. Zhang, Xie, W. M., Zhang, T., Lei, C. Z., Zhang, R. F., Xie, W. M., Zhang, T., and Lei, C. Z., High polymorphism at microsatellite loci in the Chinese donkey, vol. 15, p. -, 2016.

To reveal the genetic diversity and phylogenetic relationships between Chinese donkey breeds, 415 individuals representing ten breeds were investigated using ten microsatellite markers. The observed number of alleles, mean effective number of alleles (NE), mean expected heterozygosity (HE), and polymorphic information content (PIC) of each breed and polymorphic locus were analyzed. The results showed that seven (HTG7, HTG10, AHT4, HTG6, HMS6, HMS3, and HMS7) of ten microsatellite loci were polymorphic.

SNP at miR-483-5p-binding site in the 3'-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population

H. Y. Li, Liu, Y. C., Bai, Y. H., Sun, M., Wang, L., Zhang, X. B., Cai, B., Li, H. Y., Liu, Y. C., Bai, Y. H., Sun, M., Wang, L., Zhang, X. B., and Cai, B., SNP at miR-483-5p-binding site in the 3'-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population, vol. 15, p. -, 2016.

The aim of this study was to investigate the association between a functional variant of the basigin (BSG) gene, caused by a polymorphism (rs11473) at the miR-483-5p binding site, and the risk of esophageal squamous cell carcinoma (ESCC) in the Chinese population. The rs11473 polymorphism was genotyped in 624 esophageal cancer patients and 636 cancer-free age- and gender-matched controls using polymerase chain reaction restriction and direct sequencing.

Correlation between PPARg2 gene Pro12Ala polymorphism and cerebral infarction in an Inner Mongolian Han Chinese population

X. Li, Zhang, B. L., Zhang, X. G., Su, X. L., Li, X., Zhang, B. L., Zhang, X. G., and Su, X. L., Correlation between PPARg2 gene Pro12Ala polymorphism and cerebral infarction in an Inner Mongolian Han Chinese population, vol. 15, p. -, 2016.

The variant of PPAR-g2 has been shown to promote the increase of carotid IMT in patients suffering from cerebral infarction and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptorg2 (PPARg2) gene may be associated with cerebral infarction. However, due to the different genetic background, race, and regional variations of cerebral infarction patient, the results of investigations into this subject differ.

Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients

R. Nemati, Lu, J., Ramachandran, V., Etemad, A., Heidari, M., Yahya, M. J., Roozafzoon, R., Ismail, P., Nemati, R., Lu, J., Ramachandran, V., Etemad, A., Heidari, M., Yahya, M. J., Roozafzoon, R., and Ismail, P., Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients, vol. 15, p. -, 2016.

The aim of this study was to determine whether C34T, a common polymorphism of the adenosine monophosphate deaminase 1 gene (AMPD1), is associated with essential hypertension (EH). We hypothesize that C34T is associated with the development of EH. A case-control design was used for this study. The DNA was extracted using a commercial kit from the whole blood of 200 patients with hypertension and 200 subjects without hypertension from selected Malaysian ethnicities (Malays, Chinese, and Indians).

Meta-analysis of IL-6 -174G/C polymorphism and psoriasis risk

G. Nie, Xie, C. L., Cao, Y. J., Xu, M. M., Shi, X., Zou, A. L., Qi, J. H., Nie, G., Xie, C. L., Cao, Y. J., Xu, M. M., Shi, X., Zou, A. L., and Qi, J. H., Meta-analysis of IL-6 -174G/C polymorphism and psoriasis risk, vol. 15, p. -, 2016.

Previous studies examining the association between interleukin-6 (IL-6) -174G/C polymorphism and psoriasis risk have produced inconsistent results. The aim of this study was to offer a comprehensive review of the association between IL-6 -174G/C polymorphism and psoriasis risk through a meta-analysis. Literature search of PubMed and Embase databases was conducted to identify all eligible studies published before October 29, 2015. Four case-control studies involving 651 psoriasis cases and 552 controls were included in this meta-analysis.

Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population

J. J. Liu, Wang, W., Meng, M., Liang, C. S., Zhang, J. W., Liu, J. J., Wang, W., Meng, M., Liang, C. S., and Zhang, J. W., Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population, vol. 15, p. -, 2016.

Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine, throughout November 2015.

A comprehensive review of microRNA-related polymorphisms in gastric cancer

B. W. Han, Li, Z. H., Liu, S. F., Han, H. B., Dong, S. J., Zou, H. J., Sun, R. F., Jia, J., Han, B. W., Li, Z. H., Liu, S. F., Han, H. B., Dong, S. J., Zou, H. J., Sun, R. F., and Jia, J., A comprehensive review of microRNA-related polymorphisms in gastric cancer, vol. 15, p. -, 2016.

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regulation of expression are strongly sequence dependent.

Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population

J. J. Liu, Wang, W., Meng, M., Liang, C. S., and Zhang, J. W., Association between monoamine oxidase B A644G polymorphism and Parkinson’s disease risk: a meta-analysis in the Chinese population, vol. 15, p. -, 2016.

Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine, throughout November 2015.

Genetic variability in isolates of Chromobacterium violaceum from pulmonary secretion, water, and soil

A. C. Santini, Magalhães, J. T., Cascardo, J. C. M., Corrêa, R. X., Santini, A. C., Magalhães, J. T., Cascardo, J. C. M., Corrêa, R. X., Santini, A. C., Magalhães, J. T., Cascardo, J. C. M., and Corrêa, R. X., Genetic variability in isolates of Chromobacterium violaceum from pulmonary secretion, water, and soil, vol. 15, p. -, 2016.

Chromobacterium violaceum is a free-living Gram-negative bacillus usually found in the water and soil in tropical regions, which causes infections in humans. Chromobacteriosis is characterized by rapid dissemination and high mortality. The aim of this study was to detect the genetic variability among C. violaceum type strain ATCC 12472, and seven isolates from the environment and one from a pulmonary secretion from a chromobacteriosis patient from Ilhéus, Bahia.

Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population

K. Liang, Dong, S. R., Peng, H., Liang, K., Dong, S. R., Peng, H., Liang, K., Dong, S. R., and Peng, H., Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population, vol. 15, p. -, 2016.

We conducted a case-control study to investigate the association between IL-10-G1082A (rs1800896) polymorphism and the development of coronary artery disease (CAD) in the Chinese population. We recruited 295 CAD patients and 355 healthy controls from the Fifth Affiliated Hospital of Zhengzhou University between April 2012 and December 2014. Subjects were genotyped for IL-10-G1082A polymorphisms by using polymerase chain reaction-restriction fragment length polymorphism.

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