Polymorphism

Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma

L. H. Zhang, Hao, B. B., Zhang, C. Y., Dai, X. Z., Zhang, F., Zhang, L. H., Hao, B. B., Zhang, C. Y., Dai, X. Z., and Zhang, F., Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma, vol. 15, p. -, 2016.

Hepatocellular carcinoma is one of the most common malignant tumors worldwide; it is estimated that there were 782,000 new cases in 2012. MicroRNAs (miRNAs) play an important role in carcinogenesis by regulating oncogenes and tumor suppressors. We investigated the role of miR-146a, miR-196a2, and miR-499 polymorphisms in the risk of hepatocellular carcinoma in a Chinese population. Hepatocellular carcinoma patients (175) and healthy controls (302) were recruited between April 2013 and March 2015.

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