Polymorphism

Association between N-acetyltransferase 2 polymorphisms and pancreatic cancer risk: a meta-analysis

J. X. Liang, Gao, W., Liang, Y., and Zhou, X. M., “Association between N-acetyltransferase 2 polymorphisms and pancreatic cancer risk: a meta-analysis”, vol. 14, pp. 17219-17227, 2015.

N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results.

Meta-analysis of the TNF-α-308G/A polymorphism and vitiligo risk

G. Nie, Qi, J. H., Huang, C. W., Yang, T., Shi, N., and Chen, Y. J., “Meta-analysis of the TNF-α-308G/A polymorphism and vitiligo risk”, vol. 14, pp. 17296-17304, 2015.

Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk via a meta-analysis. Studies reporting the association between TNF-α-308G/A polymorphism and vitiligo risk were retrieved from PubMed and EmBase databases.

Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults

R. Hannum, Godoy, F. R., da Cruz, A. S., Vieira, T. C., Minasi, L. B., D. Silva, deM. e, da Silva, C. C., and da Cruz, A. D., “Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults”, vol. 14, pp. 17828-17833, 2015.

Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individual. In this study, we evaluated the single nucleotide polymorphism -1082G/A in the promoter region of interleukin-10 gene and its relationship with periodontal disease in Central Brazil.

Association between polymorphisms in the interleukin-10 gene and risk of abdominal aortic aneurysm

F. Wang, Quan, Q. Q., Zhang, C. L., Li, Y. B., and Jiang, T. B., “Association between polymorphisms in the interleukin-10 gene and risk of abdominal aortic aneurysm”, vol. 14, pp. 17599-17604, 2015.

In this case-control study, we attempted to investigate the role of three common single nucleotide polymorphisms (SNPs; -1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) in the IL-10 gene in the development of abdominal aortic aneurysm in a Chinese population. Three hundred and eighty-one patients with abdominal aortic aneurysm and age- and gender-matched healthy controls (N = 381) were collected between March 2012 and March 2014.

Genetic relatedness of artichoke (Cynara scolymus L.) hybrids using random amplified polymorphic DNA (RAPD) fingerprinting

M. A. Sharaf-Eldin, Al-Tamimi, A., Alam, P., Elkholy, S. F., and Jordan, J. R., “Genetic relatedness of artichoke (Cynara scolymus L.) hybrids using random amplified polymorphic DNA (RAPD) fingerprinting”, vol. 14, pp. 18431-18439, 2015.

The artichoke (Cynara scolymus L.) is an important food and medicinal crop that is cultivated in Mediterranean countries. Morphological characteristics, such as head shape and diameter, leaf shape, and bract shape, are mainly affected by environmental conditions. A molecular marker approach was used to analyze the degree of polymorphism between artichoke hybrid lines. The degree of genetic difference among three artichoke hybrids was evaluated using random amplified polymorphic DNA-PCR (RAPD-PCR).

Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis

Y. - F. Yu, Han, Z. - G., Guo, W. - B., Zhang, G. - J., Yang, J. - K., Wu, F. - L., Ou, Q. - Y., Li, Y. - H., Cai, X. - Y., Zhan, Z. - N., Chen, J. - H., Xie, W. - L., Tang, L., and Liu, C. - D., “Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis”, vol. 14, pp. 18945-18957, 2015.

It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort studies were quantitatively analyzed to evaluate IL-10 promoter gene polymorphisms and NPC risk.

Glutathione S-transferase polymorphisms in varicocele patients: a meta-analysis

B. Zhu, Yin, L., and Zhang, J. Y., “Glutathione S-transferase polymorphisms in varicocele patients: a meta-analysis”, vol. 14, pp. 18851-18858, 2015.

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 control subjects. A systematic literature search (for articles published up to September 2014) utilizing Google Scholar and PubMed was conducted.

Association of the PPARγ2 Pro12Ala polymorphism with increased risk of cardiovascular diseases

Y. Li, Zhu, J., and Ding, J. Q., “Association of the PPARγ2 Pro12Ala polymorphism with increased risk of cardiovascular diseases”, vol. 14, pp. 18662-18674, 2015.

This meta-analysis investigated the correlation between the PPARγ2 Pro12Ala polymorphism and cardiovascular disease (CVD). Electronic database and manual searches were conducted to retrieve studies published relevant to the PPARγ2 Pro12Ala polymorphism and CVD. Rigorous inclusion and exclusion criteria were employed for selection of high-quality patients-control studies.

Association of LTβR gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population

S. H. Lee, Kim, S. K., Yoo, K. H., Chung, J. H., and Chang, S. G., “Association of LTβR gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population”, vol. 14, pp. 18607-18615, 2015.

The lymphotoxin-β receptor (LTβR) gene is involved in autoimmune disease and inflammatory disorder development, but the relationship between LTβR and benign prostatic hyperplasia (BPH) is unclear. In total, 222 with BPH were examined for 3 single nucleotide polymorphisms [rs3759333 (-1387C/T), rs3759334 (-1326A/G), and rs2364480 (Ala172Ala)] located in the promoter and coding regions of LTβR using direct sequencing.

Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis

L. L. Zhang, Wang, Y. Q., Fu, B., Zhao, S. L., and Kui, Y., “Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis”, vol. 14, pp. 18503-18514, 2015.

We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association. We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases. Statistical analysis was performed using Revman 5.0 and Stata12.0 softwares. A total of 3305 cases and 5016 controls in 12 case-control studies were included in this meta-analysis.

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