Genetic variability of DNA repair mechanisms in chemotherapy treatment outcome of gastric cancer patients
“Genetic variability of DNA repair mechanisms in chemotherapy treatment outcome of gastric cancer patients”, vol. 14, pp. 17228-17234, 2015.,
We investigate whether three common polymorphisms in ERCC1 and ERCC2 are predictor factors for the chemotherapy response, as well as the clinic outcome of patients with gastric cancer. Between May 2011 and May 2013, 263 patients with gastric cancer who were newly diagnosed by histopathology were enrolled in our study. Genotyping of the ERCC1 rs11615 and rs3212986, and ERCC2 rs1799793 polymorphisms were conducted by the polymerase chain reaction-restriction fragment length polymorphism assay.