Polymorphism

Effect of IL-1β, IL-8, and IL-10 polymorphisms on the development of myocardial infarction

S. Wang, Dai, Y. X., Chen, L. L., Jiang, T., Zheng, M. Q., Li, C. G., Chen, Y. P., Lin, W. H., Zhang, J. F., and Jiang, J., Effect of IL-1β, IL-8, and IL-10 polymorphisms on the development of myocardial infarction, vol. 14, pp. 12016-12021, 2015.

Myocardial infarction (MI) is currently a leading cause of death worldwide, and is caused by various environmental and genetic factors. We therefore conducted a case-control study to investigate the association between polymorphisms in interleukins IL-1β, IL-8, and IL-10 and MI risk. This study recruited 260 MI patients and 285 control subjects. Genotyping of IL-1β +3954C/T, IL-8 -251T/A, IL-10 -1082A/G, and IL-10 -819C/T were assessed using the polymerase chain reaction-restriction fragment length polymorphism method.

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